Non-coding RNAs and disease: the classical ncRNAs make a comeback-Reference-Cited by-同舟云学术

Non-coding RNAs and disease: the classical ncRNAs make a comeback

Published:2016-08-15 Issue:4 Volume:44 Page:1073-1078
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

de Almeida Rogerio Alves¹,Fraczek Marcin G.¹,Parker Steven¹,Delneri Daniela¹,O'Keefe Raymond T.¹

Affiliation:

1. Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, U.K.

Abstract

Many human diseases have been attributed to mutation in the protein coding regions of the human genome. The protein coding portion of the human genome, however, is very small compared with the non-coding portion of the genome. As such, there are a disproportionate number of diseases attributed to the coding compared with the non-coding portion of the genome. It is now clear that the non-coding portion of the genome produces many functional non-coding RNAs and these RNAs are slowly being linked to human diseases. Here we discuss examples where mutation in classical non-coding RNAs have been attributed to human disease and identify the future potential for the non-coding portion of the genome in disease biology.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/44/4/1073/486465/bst0441073.pdf

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