Transporter oligomerization: form and function

Author:

Alguel Yilmaz1,Cameron Alexander D.2,Diallinas George3,Byrne Bernadette1

Affiliation:

1. Department of Life Sciences, Imperial College London, London SW7 2AZ, U.K.

2. School of Life Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, U.K.

3. Department of Biology, National and Kapodistrian University of Athens, Panepistimioupolis 15781 Athens, Greece

Abstract

Transporters are integral membrane proteins with central roles in the efficient movement of molecules across biological membranes. Many transporters exist as oligomers in the membrane. Depending on the individual transport protein, oligomerization can have roles in membrane trafficking, function, regulation and turnover. For example, our recent studies on UapA, a nucleobase ascorbate transporter, from Aspergillus nidulans, have revealed both that dimerization of this protein is essential for correct trafficking to the membrane and the structural basis of how one UapA protomer can affect the function of the closely associated adjacent protomer. Here, we review the roles of oligomerization in many particularly well-studied transporters and transporter families.

Publisher

Portland Press Ltd.

Subject

Biochemistry

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