Extracellular regulation of BMP signaling: welcome to the matrix-Reference-Cited by-同舟云学术

Extracellular regulation of BMP signaling: welcome to the matrix

Published:2017-02-08 Issue:1 Volume:45 Page:173-181
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Sedlmeier Georg¹,Sleeman Jonathan P.¹²

Affiliation:

1. Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, University Heidelberg, 68167 Mannheim, Germany

2. Institute for Toxicology and Genetics, Karlsruhe Institute of Technology Campus Nord, 76021 Karlsruhe, Germany

Abstract

Given its importance in development and homeostasis, bone morphogenetic protein (BMP) signaling is tightly regulated at the extra- and intracellular level. The extracellular matrix (ECM) was initially thought to act as a passive mechanical barrier that sequesters BMPs. However, a new understanding about how the ECM plays an instructive role in regulating BMP signaling is emerging. In this mini-review, we discuss various ways in which the biochemical and physical properties of the ECM regulate BMP signaling.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/45/1/173/432789/bst-2016-0263.pdf

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