Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins

Author:

Coelho Miguel B.1,Ascher David B.1,Gooding Clare1,Lang Emma1,Maude Hannah1,Turner David1,Llorian Miriam1,Pires Douglas E.V.12,Attig Jan3,Smith Christopher W.J.1

Affiliation:

1. Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, U.K.

2. Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Avenida Augusto de Lima 1715, Belo Horizonte 30190-002, Brazil

3. Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London WC1N 3BG, U.K.

Abstract

Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm. PTBP1 has four RNA binding domains of the RNA recognition motif (RRM) family, each of which can bind to pyrimidine motifs. In addition, RRM2 can interact via its dorsal surface with proteins containing short peptide ligands known as PTB RRM2 interacting (PRI) motifs, originally found in the protein Raver1. Here we review our recent progress in understanding the interactions of PTB with RNA and with various proteins containing PRI ligands.

Publisher

Portland Press Ltd.

Subject

Biochemistry

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