Affiliation:
1. Department of Biochemistry, Charing Cross and Westminster Medical School, University of London, Fulham Palace Road, London W6 8RF, U.K.
Abstract
The rat chondrosarcoma chondrocyte has the dual capacity to metabolize glucose (mainly via glycolysis) and glutamine (via an oxidative pathway). Glutamine metabolism, unlike that of glucose, is unable to sustain intracellular ATP concentrations. Glutamine consumption by the chondrosarcoma chondrocyte, however, is significantly in excess of its utilization as an amide-group donor in hexosamine synthesis, implying a novel and major role in cell metabolism.
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
25 articles.
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