The biocompatibility of biofuel cells operating inside the body

Author:

Penven Geraldine1,Menassol Gauthier1,Alcaraz Jean-Pierre1,Boucher François2,Thélu Jacques1,El Ichi Sarra1,Dubois Lionel3,Zebda Abdelkader1,Cinquin Philippe1,Martin Donald K.1ORCID

Affiliation:

1. Univ. Grenoble Alpes, CNRS, TIMC-IMAG/SyNaBi (UMR 5525), 38000 Grenoble, France

2. Univ. Grenoble Alpes, CNRS, TIMC-IMAG/PRETA (UMR 5525), 38000 Grenoble, France

3. Univ. Grenoble Alpes, CEA, CNRS, IRIG-SyMMES, 38000 Grenoble, France

Abstract

In 1968 Wolfson et al. published the concept for producing energy inside the body using catalytic electrodes exposed to the body fluid as an electrolyte and utilising naturally occurring fuels such as glucose. Since then, the technology has advanced to enhance the levels of power using enzymes immobilised within three-dimensional bioelectrodes that are nanostructured. Current research in the field of enzymatic fuel cells is directed toward applying electrochemical and nanostructural expertise to increase the energy density, to increase the power density, to increase the operational stability, and to increase the voltage output. Nonetheless, biocompatibility remains the major challenge for increasing the life-time for implanted enzymatic biofuel cells. Here, we discuss the current issues for biocompatibility and suggest directions to enhance the design of biofuel cells so as to increase the life-time of implantation whilst maintaining sufficient performance to provide power for implanted medical devices.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Reference40 articles.

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1. In-situ n-doped 3D-printed abiotic cathodes for implantable biofuel cells;Journal of Applied Electrochemistry;2024-07-11

2. 3D printed cathodes for implantable abiotic biofuel cells;Journal of Power Sources;2023-10

3. Bio‐fuel cell for medical device energy system: A review;International Journal of Energy Research;2021-04-30

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