Affiliation:
1. Department of Biochemistry, University of Bristol, Bristol BS8 1TD, U.K.
Abstract
The iron-binding ability of apotransferrins is rapidly abolished in the reaction with periodate anions, which destroys 4 mol of tyrosine per mol of protein. Treatment of ovotransferrin with cyanogen bromide and tryptic digestion of the glycopeptide fragment demonstrated the existence of an intramolecular cross-link in the C-terminal domain of the oxidized protein. The cross-linked residues were identified as Tyr-421 and Tyr-524 and the product is similar in structure to 3,3′-dityrosine.
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
11 articles.
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