Inhibition of poly(ADP-ribose) formation by 4-hydroxynonenal in primary cultures of rabbit synovial fibroblasts-Reference-Cited by-同舟云学术

Inhibition of poly(ADP-ribose) formation by 4-hydroxynonenal in primary cultures of rabbit synovial fibroblasts

Published:1996-05-01 Issue:3 Volume:315 Page:705-708
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

ULLRICH Oliver¹,SIEMS Werner G.²,LEHMANN Kerstin¹,HUSER Hans³,EHRLICH Wilhelm³,GRUNE Tilman¹

Affiliation:

1. Clinics of Physical Therapy and Rehabilitation, Medical Faculty (Charité), Humboldt University Berlin, Schumannstrasse 20–21, D-10098 Berlin, Federal Republic of Germany

2. Herzog-Julius Hospital for Rheumatology and Orthopedics, Kurhausstrasse 13–17, D-38655 Bad Harzburg, Federal Republic of Germany

3. Robert-Koch-Institut, Department of Biochemistry, Nordufer 20, D-13353 Berlin, Federal Republic of Germany

Abstract

The formation of poly(ADP-ribose) in primary cultures of rabbit synovial fibroblasts after treatment with active oxygen released by xanthine/xanthine oxidase is inhibited by addition of 1 and 10 μM 4-hydroxy-2,3-trans-nonenal (HNE). The endogenous formation of HNE by the xanthine/xanthine oxidase system is not responsible for the inhibitory effect of the aldehyde, owing to the low accumulation rate of the lipid peroxidation product in the system used. HNE is able to inhibit the isolated nuclear enzyme ADP-ribosyltransferase, as shown by an in vitro assay with an Ki of 4 μmol/litre. Therefore the molecular basis of HNE-mediated effects on cell proliferation, differentiation and transformation might be due to the inhibitory effect of poly(ADP-ribos)ylation.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/315/3/705/728913/bj3150705.pdf

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