Glucose-6-phosphatase in normal adult human intestinal mucosa-Reference-Cited by-同舟云学术

Glucose-6-phosphatase in normal adult human intestinal mucosa

Published:1992-12-01 Issue:6 Volume:83 Page:683-687
ISSN:0143-5221
Container-title:Clinical Science
language:en
Short-container-title:

Author:

Pears John¹,Jung Roland T.¹,Jankowski John¹,Waddell Ian D.²,Burchell Ann²

Affiliation:

1. Deapartment of Medicine, Ninewells Hospital and Medical School, Dundee, U.K.

2. Centre for Research into Human Development, Department of Obstetrics and Gynaecology and Department of Child Health, Ninewells Hospital and Medical School, Dundee, U.K.

Abstract

1. The existence of specific glucose-6-phosphatase activity in human intestinal mucosa has been somewhat controversial. 2. We have demonstrated the presence of low levels of specific glucose-6-phosphatase activity in normal human adult intestinal mucosa. Activity was found in oesophagus, stomach, duodenum and colon. 3. Immunoblot analysis using antibodies monospecific for the 36.5 kDa liver glucose-6-phosphatase catalytic subunit demonstrated that intestinal mucosa contains low levels of the glucose-6-phosphatase enzyme protein. 4. The low levels of activity together with problems of proteolysis make human intestinal biopsies unsuitable for use in the diagnosis of type 1 glycogen-storage disease.

Publisher

Portland Press Ltd.

Subject

General Medicine

Link

https://portlandpress.com/clinsci/article-pdf/83/6/683/463833/cs0830683.pdf

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Utilization of cornstarch in glycogen storage disease type Ia;European Journal of Gastroenterology & Hepatology;2002-11

2. A different isoform of the transport protein mutated in the glycogen storage disease 1b is expressed in brain;FEBS Letters;1998-08-14

3. Human Fetal Testis Endoplasmic Reticulum Glucose-6-Phosphatase Enzyme Protein1;Biology of Reproduction;1996-08-01

4. The glucose-6-phosphatase enzyme in developing human trachea and oesophagus;The Histochemical Journal;1996-02

5. Low levels of glucose-6-phosphate hydrolysis in the sarcoplasmic reticulum of skeletal muscle;Molecular Membrane Biology;1996-01