STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1-Reference-Cited by-同舟云学术

STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1

Published:2015-03-06 Issue:3 Volume:466 Page:511-524
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Blaszczyk Katarzyna¹,Olejnik Adam¹,Nowicka Hanna¹,Ozgyin Lilla²,Chen Yi-Ling³,Chmielewski Stefan¹,Kostyrko Kaja¹,Wesoly Joanna⁴,Balint Balint Laszlo²,Lee Chien-Kuo³,Bluyssen Hans A.R.¹

Affiliation:

1. Department of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland

2. University of Debrecen/Medical Faculty, Department of Biochemistry and Molecular Biology Centre for Clinical Genomics and Personalized Medicine, Debrecen, Hungary

3. Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan

4. Laboratory of High Throughput Technologies, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland

Abstract

Collectively our results strongly suggest that the alternative IFNα-mediated, STAT2/IRF9 dependent signaling pathway can induce a prolonged ISGF3-like transcriptome and generate an antiviral response analogous to ISGF3, independent of STAT1. Moreover, the existence of “STAT2/IRF9-specific” target genes predicts a novel role of STAT2 in IFNα signaling.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/466/3/511/736064/bj4660511.pdf

Reference43 articles.

1. Interferons, interferon-like cytokines, and their receptors;Pestka;Immunol. Rev.,2004

2. JAK-STAT signaling: from interferons to cytokines;Schindler;J. Biol. Chem.,2007

3. Interferon-lambda: a new addition to an old family;Donnelly;J. Interferon Cytokine Res.,2010

4. IFN gamma-dependent SOCS3 expression inhibits IL-6-induced STAT3 phosphorylation and differentially affects IL-6 mediated transcriptional responses in endothelial cells;Bluyssen;Am. J. Physiol. Cell Physiol.,2010

5. STAT activation and differential complex formation dictate selectivity of interferon responses;Wesoly;Acta Biochim. Pol.,2007

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