αvβ6 integrin is required for TGFβ1-mediated matrix metalloproteinase2 expression-Reference-Cited by-同舟云学术

αvβ6 integrin is required for TGFβ1-mediated matrix metalloproteinase2 expression

Published:2015-03-06 Issue:3 Volume:466 Page:525-536
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Dutta Anindita¹²,Li Jing¹,Fedele Carmine¹²,Sayeed Aejaz¹²,Singh Amrita¹²,Violette Shelia M.³,Manes Thomas D.⁴,Languino Lucia R.¹²

Affiliation:

1. Prostate Cancer Discovery and Development Program

2. Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, U.S.A.

3. Biogen Idec, Inc., Cambridge, MA 02142, U.S.A.

4. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, U.S.A.

Abstract

The present study establishes that the avβ6 integrin associates with the transforming growth factor (TGF)β receptor (TβR) and is required for the activation of the TGFβ–Smad3 signalling pathway. This causes up-regulation of matrix metalloproteinase (MMP)2 and as a result avβ6 promotes cell migration in an MMP2-dependent manner.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/466/3/525/736054/bj4660525.pdf

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