The mitochondrial citrate carrier: a new player in inflammation-Reference-Cited by-同舟云学术

The mitochondrial citrate carrier: a new player in inflammation

Published:2011-08-26 Issue:3 Volume:438 Page:433-436
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Infantino Vittoria¹²,Convertini Paolo¹,Cucci Liana³,Panaro Maria Antonietta³,Di Noia Maria Antonietta¹²,Calvello Rosa¹,Palmieri Ferdinando¹⁴,Iacobazzi Vito¹⁴

Affiliation:

1. Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, 70125 Bari, Italy

2. Department of Chemistry, University of Basilicata, 85100 Potenza, Italy

3. Department of Human Anatomy and Histology, University of Bari, 70124 Bari, Italy

4. CNR Institute of Biomembranes and Bioenergetics, 70125 Bari, Italy

Abstract

The mitochondrial CIC (citrate carrier) catalyses the efflux of citrate from the mitochondrial matrix in exchange for cytosolic malate. In the present paper we show that CIC mRNA and protein markedly increase in lipopolysaccharide-activated immune cells. Moreover, CIC gene silencing and CIC activity inhibition significantly reduce production of NO, reactive oxygen species and prostaglandins. These results demonstrate for the first time that CIC has a critical role in inflammation.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/438/3/433/668787/bj4380433.pdf

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