Superficial Hand Vein Responses to NG-Monomethyl-l-Arginine in Post-Partum and Non-Pregnant Women

Author:

Ford G. A.1,Robson S. C.2,Mahdy Z. A.2

Affiliation:

1. Department of Pharmacological Sciences, The University, Newcastle Upon Tyne, U.K.

2. Department of Obstetrics and Gynaecology, The University, Newcastle Upon Tyne, U.K.

Abstract

1. During human pregnancy marked vasodilatation occurs in arterial and venous vascular beds. The mechanisms responsible for this change remain unclear. The contribution of increased nitric oxide activity to vasodilatation associated with pregnancy was determined by examining superficial hand vein responses to NG-monomethyl-l-arginine, an inhibitor of nitric oxide synthase, in post-partum women 24–48 h after delivery when vasodilatation remains at levels present during the third trimester. 2. Seventeen healthy women, 24–48 h post partum, and 13 healthy non-pregnant women were studied. Eight of the post-partum women underwent repeat studies 12–16 weeks after delivery. 3. NG-monomethyl-l-arginine (100 nmol/min) resulted in venoconstriction in non-constricted veins (baseline, 0%; 5 min, 26 ± 9%; 10 min, 14 ± 8%; 15 min, 8 ± 7%; means ± SEM) and noradrenaline-constricted veins (5 min, 30 ± 7%; 10 min, 24 ± 10%; 15 min, 14 ± 11%). No constrictor response to NG-monomethyl-l-arginine was present in the same women 12 weeks post partum (5 min, 1 ± 4%; 10 min, 0 ± 3%; 15 min, 1 ± 4%) or in the non-pregnant control subjects in non-constricted (5 min, 2 ± 3%; 10 min, 4 ± 3%; 15 min, 2 ± 2%) or noradrenaline-constricted veins (Smin, − 2 ± 7%; 10 min, 1 ± 9%; 15 min, − 5 ± 7%). 4. These findings indicate that nitric oxide activity is increased in the immediate post-partum period in venous vasculature, and support the hypothesis that increased nitric oxide activity may be responsible for the vasodilatation observed during normal pregnancy.

Publisher

Portland Press Ltd.

Subject

General Medicine

Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Mechanisms Underlying Maternal Venous Adaptation in Pregnancy;Reproductive Sciences;2009-03-24

2. Forearm blood flow in pre-eclampsia;BJOG-INT J OBSTET GY;2003

3. Forearm blood flow in pre-eclampsia;BJOG: An International Journal of Obstetrics and Gynaecology;2003-04

4. Endothelial factors;Pre-eclampsia;2001-01-01

5. Stimulated nitric oxide release and nitric oxide sensitivity in forearm arterial vasculature during normotensive and preeclamptic pregnancy;American Journal of Obstetrics and Gynecology;1999-12

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