New perspectives of the cardiac cellular landscape: mapping cellular mediators of cardiac fibrosis using single-cell transcriptomics

Author:

Krstevski Crisdion12,Cohen Charles D.12,Dona Malathi S.I.1,Pinto Alexander R.12ORCID

Affiliation:

1. Cardiac Cellular Systems, Baker Heart and Diabetes Institute, Prahran, VIC, Australia

2. Centre for Cardiovascular Biology and Disease Research, La Trobe University, Melbourne, VIC, Australia

Abstract

Single-cell transcriptomics enables inference of context-dependent phenotypes of individual cells and determination of cellular diversity of complex tissues. Cardiac fibrosis is a leading factor in the development of heart failure and a major cause of morbidity and mortality worldwide with no effective treatment. Single-cell RNA-sequencing (scRNA-seq) offers a promising new platform to identify new cellular and molecular protagonists that may drive cardiac fibrosis and development of heart failure. This review will summarize the application scRNA-seq for understanding cardiac fibrosis and development of heart failure. We will also discuss some key considerations in interpreting scRNA-seq data and some of its limitations.

Publisher

Portland Press Ltd.

Subject

Biochemistry

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