Factor Xa dimerization competes with prothrombinase complex formation on platelet-like membrane surfaces-Reference-Cited by-同舟云学术

Factor Xa dimerization competes with prothrombinase complex formation on platelet-like membrane surfaces

Published:2015-03-20 Issue:1 Volume:467 Page:37-46
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Koklic Tilen¹,Chattopadhyay Rima²,Majumder Rinku²,Lentz Barry R.²

Affiliation:

1. Laboratory of Biophysics, Condensed Matter Physics Department, Jožef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia

2. Department of Biochemistry and Biophysics & Program in Molecular and Cellular Biophysics, University of North Carolina, Chapel Hill, NC 27599-7260, U.S.A.

Abstract

Factor Va competes factor Xa off of inactive factor Xa dimers to amplify thrombin production, both because it releases dimer inhibition and because of its cofactor activity. This suggests an unanticipated mechanism by which platelet membranes can regulate blood coagulation.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/467/1/37/683187/bj4670037.pdf

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