Binding of diethylstilboestrol to deoxyribonucleic acid by rat liver microsomal fractions in vitro and in mouse foetal cells in culture-Reference-Cited by-同舟云学术

Binding of diethylstilboestrol to deoxyribonucleic acid by rat liver microsomal fractions in vitro and in mouse foetal cells in culture

Published:1976-09-15 Issue:3 Volume:158 Page:643-646
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Blackburn G M¹,Thompson M H¹²,King H W S²

Affiliation:

1. Department of Chemistry, University of Sheffield, Sheffield S3 7HF, U.K.

2. *† Institute of Cancer Research, Pollards Wood Research Station, Chalfont St. Giles, Bucks. HP8 4SP, U.K.

Abstract

Diethylstillboestrol, a synthetic and carcinogenic hormone, binds to DNA as a result of incubation with a liver microsomal preparation in vitro and on incubation with primary mouse foetal cells in culture. Enzymic digestion of DNA samples thus prepared gives several covalent deoxyribonucleoside-diethylstilboestrol products from the microsomal system. One of these is produced in small but significant yield in the tissue-culture system.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/158/3/643/567752/bj1580643.pdf

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