The role of ESCRT proteins in attenuation of cell signalling-Reference-Cited by-同舟云学术

The role of ESCRT proteins in attenuation of cell signalling

Published:2009-01-20 Issue:1 Volume:37 Page:137-142
ISSN:0300-5127
Container-title:Biochemical Society Transactions
language:en
Short-container-title:

Author:

Rodahl Lina M.¹,Stuffers Susanne¹,Lobert Viola H.¹,Stenmark Harald¹

Affiliation:

1. Centre for Cancer Biomedicine, Faculty Division, Norwegian Radium Hospital, University of Oslo, N-0310 Oslo, Norway, and Department of Biochemistry, Institute for Cancer Research, Rikshospitalet University Hospital, Montebello, N-0310 Oslo, Norway

Abstract

The ESCRT (endosomal sorting complex required for transport) machinery consists of four protein complexes that mediate sorting of ubiquitinated membrane proteins into the intraluminal vesicles of multivesicular endosomes, thereby targeting them for degradation in lysosomes. In the present paper, we review how ESCRT-mediated receptor down-regulation affects signalling downstream of Notch and growth factor receptors, and how ESCRTs may control cell proliferation, survival and cytoskeletal functions and contribute to tumour suppression.

Publisher

Portland Press Ltd.

Subject

Biochemistry

Link

https://portlandpress.com/biochemsoctrans/article-pdf/37/1/137/546033/bst0370137.pdf

Reference52 articles.

1. Endosomal and non-endosomal functions of ESCRT proteins;Slagsvold;Trends Cell Biol.,2006

2. Receptor downregulation and multivesicular-body sorting;Katzmann;Nat. Rev. Mol. Cell Biol.,2002

3. Vps27 recruits ESCRT machinery to endosomes during MVB sorting;Katzmann;J. Cell Biol.,2003

4. Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes;Bache;J. Cell Biol.,2003

5. TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation;Lu;Proc. Natl. Acad. Sci. U.S.A.,2003

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