1. 1Department of Medicine, The Medical School, The University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
2. 2Department of Medicine, The Medical School, The University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.
3. 3Department of Medicine, The Medical School, The University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, U.K.