Author:
Brown B L,Wojcikiewicz R J H,Dobson P R M,Robinson A,Irons L I
Abstract
The inhibition of prolactin secretion and cyclic AMP accumulation in GH3 cells by muscarinic agonists was blocked by preincubation of the cells with pertussis toxin (islet-activating protein). There was a lag of approx. 80 min in the onset of the effect on secretion. These results suggest that muscarinic agonists decrease prolactin secretion by inhibiting adenylate cyclase activity.
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
28 articles.
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