CENP-A nucleosome—a chromatin-embedded pedestal for the centromere: lessons learned from structural biology-Reference-Cited by-同舟云学术

CENP-A nucleosome—a chromatin-embedded pedestal for the centromere: lessons learned from structural biology

Published:2020-07-28 Issue:2 Volume:64 Page:205-221
ISSN:0071-1365
Container-title:Essays in Biochemistry
language:en
Short-container-title:

Author:

Ali-Ahmad Ahmad¹,Sekulić Nikolina¹²^ORCID

Affiliation:

1. Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, Faculty of Medicine, University of Oslo, Oslo 0318, Norway

2. Department of Chemistry, University of Oslo, P.O. Box 1033, Blindern NO-0315, Norway

Abstract

Abstract The centromere is a chromosome locus that directs equal segregation of chromosomes during cell division. A nucleosome containing the histone H3 variant CENP-A epigenetically defines the centromere. Here, we summarize findings from recent structural biology studies, including several CryoEM structures, that contributed to elucidate specific features of the CENP-A nucleosome and molecular determinants of its interactions with CENP-C and CENP-N, the only two centromere proteins that directly bind to it. Based on those findings, we propose a role of the CENP-A nucleosome in the organization of centromeric chromatin beyond binding centromeric proteins.

Publisher

Portland Press Ltd.

Subject

Molecular Biology,Biochemistry

Link

https://portlandpress.com/essaysbiochem/article-pdf/64/2/205/892448/ebc-2019-0074c.pdf

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