Effect on uridine diphosphate glucuronyltransferase activity of depleting and restoring phospholipids to guinea-pig liver microsomal preparations-Reference-Cited by-同舟云学术

Effect on uridine diphosphate glucuronyltransferase activity of depleting and restoring phospholipids to guinea-pig liver microsomal preparations

Published:1976-03-15 Issue:3 Volume:154 Page:783-785
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Berry C S.¹,Caldecourt M¹,Hallinan T¹

Affiliation:

1. Department of Biochemistry antd Chemistry, Royal Free Hospital Medical School, 8 Hunter Street, London WCIN 1BP, U.K.

Abstract

Phospholipid depletion substantially inhibited the maximum demonstrable activities of the forward (glucuronidation) and reverse reactions of UDP-glucuronyltransferase towards p-nitrophenol in guinea-pig liver microsomal preparations. Dispersions of liver phospholipids restored activity, whereas non-phospholipid amphipaths failed to do so effectively. These results suggest that the system is probably phospholipid-dependent rather than conformationally constrained by phospholipids.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/154/3/783/567124/bj1540783.pdf

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