Lack of angiotensin I accumulation after converting enzyme blockade by enalapril or lisinopril in man

Abstract

1. In nine normal volunteers, a series of five venous blood samples was obtained before and up to 24 h after converting enzyme inhibition by a single oral dose of enalapril or lisinopril. Plasma renin activity and blood angiotensin I were measured. 2. A close linear relationship was found between the increase in plasma renin activity and the increase in blood angiotensin I. 3. The linear correlation between plasma renin activity and blood angiotensin I remained after converting enzyme inhibition. 4. Thus, the rise in angiotensin I after inhibition of the conversion of angiotensin I to angiotensin II is due to an enhanced release of renin rather than to accumulation of angiotensin I.