Affiliation:
1. Wellcome Research Laboratories, Langley Court, Beckenham, Kent BR3 3BS, U.K.
Abstract
Stimulated rat peritoneal neutrophils release a platelet inhibitory factor with the pharmacological properties of NO. This release is inhibited by NG-monomethyl-L-arginine and L-canavanine, indicating that it occurs through a mechanism similar to that in vascular endothelial cells and macrophages. As the degree of stimulation increases, the factor released is progressively inactivated by concomitant release of superoxide anions.
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
554 articles.
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