Thyroidal extracellular glutathione peroxidase: a potential regulator of thyroid-hormone synthesis-Reference-Cited by-同舟云学术

Thyroidal extracellular glutathione peroxidase: a potential regulator of thyroid-hormone synthesis

Published:1995-06-15 Issue:3 Volume:308 Page:713-717
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Howie A F¹,Walker S W¹,Åkesson B²,Arthur J R³,Beckett G J¹

Affiliation:

1. Cellular Endocrinology Unit, University Department of Clinical Biochemistry, Royal Infirmary, Edinburgh EH3 9YW, U.K.,

2. Department of Applied Nutrition and Food Chemistry, Chemical Centre, University of Lund, P.O. Box 124, S-221 00 Lund, Sweden,

3. Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB, U.K.

Abstract

Human thyrocytes were found to synthesize and secrete the selenoenzyme extracellular glutathione peroxidase (E-GPX), a process which was controlled by the Ca2+/phosphoinositol second-messenger cascade. The potential involvement of thyroidal E-GPX in the regulation of thyroid-hormone synthesis and in the protection of the thyrocyte from peroxidative damage is discussed.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/308/3/713/620815/bj3080713.pdf

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