Deregulation of ribosomal proteins in human cancers

Author:

El Khoury Wendy1,Nasr Zeina1ORCID

Affiliation:

1. Department of Biology, Faculty of Arts and Sciences, University of Balamand, Lebanon

Abstract

Abstract The ribosome, the site for protein synthesis, is composed of ribosomal RNAs (rRNAs) and ribosomal proteins (RPs). The latter have been shown to have many ribosomal and extraribosomal functions. RPs are implicated in a variety of pathological processes, especially tumorigenesis and cell transformation. In this review, we will focus on the recent advances that shed light on the effects of RPs deregulation in different types of cancer and their roles in regulating the tumor cell fate.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

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