Affiliation:
1. Department of Basic Medical Sciences, St George's Hospital Medical School, Cranmer Terrace, London SW17 ORE, U.K.
Abstract
β-Amyloid, a neurotoxic peptide deposited in the brains of Alzheimer's disease patients, is released by a series of membrane-limited proteolytic events. β-Secretase activity is enhanced by cellular targeting into intracellular cholesterol-rich microdomains, which are dispersed by statins.
Cited by
11 articles.
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