Conversion of pepsinogen into pepsin is not a one-step process-Reference-Cited by-同舟云学术

Conversion of pepsinogen into pepsin is not a one-step process

Published:1976-01-01 Issue:1 Volume:153 Page:141-144
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Dykes C W¹,Kay J¹

Affiliation:

1. Department of Biochemistry, University College, Cardiff CFl 1 XL, U.K.

Abstract

By incubation of pepsinogen with pepstatin at pH2.5, the first ‘active’ protein generated on activation is trapped in an inactive complex. The first activation peptide liberated has been identified as residues 1-16 from the pepsinogen sequence. This suggests a sequential mechanism rather than a one-step formation of pepsin.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/153/1/141/565366/bj1530141.pdf

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