Affiliation:
1. Medical Research Council Unit for Metabolic Studies in Psychiatry, University Department of Psychiatry, Middlewood Hospital, P.O. Box 134, Sheffield S6 1TP, U.K.
Abstract
The urine of a patient with argininosuccinicaciduria contains several previously undescribed compounds that can be derived chemically from argininosuccinic anhydride (I). One of the major compounds is 8-carboxy-2-carboxymethyl-3-oxo-2,3,5,6,7,8-hexa-hydro-1H-imidazo [1,2-a][1,3]diazepine, which exists as two diastereoisomers that are readily interconvertible at pH5. The corresponding ring-opened monocyclic diazepines are also present, as well as traces of the isomeric hexahydroimidazodiazepines that are formally related to argininosuccinic anhydride (II). The formation and stereochemistry of these compounds are discussed.
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12 articles.
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