Affiliation:
1. Department of Biological Chemistry, University of California at Davis Medical School, Davis, CA 95616, U.S.A.
Abstract
An orphan receptor resembling the neurokinin 3 tachykinin receptor (NK3), initially claimed to be an atypical opioid receptor, is shown herein to respond potently to the physiological NK3 receptor ligand, neurokinin B. This ‘NK4’ receptor did not give functional responses in Xenopus oocytes to opioid agonists. However, NK4 receptor activation was inhibited by nanomolar concentrations of dynorphin. The NK4 receptor is therefore a tachykinin receptor which is functionally antagonized by an endogenous opioid peptide.
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
43 articles.
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1. The Concise Guide to PHARMACOLOGY 2013/14: G Protein-Coupled Receptors;British Journal of Pharmacology;2013-12
2. Neurokinin B and pre-eclampsia: a decade of discovery;Reproductive Biology and Endocrinology;2010-01-14
3. Tachykinin;British Journal of Pharmacology;2009-11
4. 7TM RECEPTORS;British Journal of Pharmacology;2009-11
5. Tachykinins and Neurogenic Inflammation at Visceral Level;Neurogenic Inflammation in Health and Disease;2009