Affiliation:
1. Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, London, S.W. 3
Abstract
Spectrophotometric assay methods are described for glutathione synthetase, γ-glutamylcysteine synthetase and γ-glutamyl transpeptidase of erythrocytes. The contents of these enzymes in normal human erythrocytes are reported. Erythrocyte glutathione synthetase is inhibited by ADP; this inhibition is competitive with respect to ATP. γ-Glutamylcysteine synthetase is subject to feedback inhibition by GSH, and is also inhibited by NADH, and to a lesser extent by NAD+ and NADPH. This enzyme is irreversibly inactivated by cysteamine.
Cited by
70 articles.
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