O-GlcNAcylation of co-activator-associated arginine methyltransferase 1 regulates its protein substrate specificity-Reference-Cited by-同舟云学术

O-GlcNAcylation of co-activator-associated arginine methyltransferase 1 regulates its protein substrate specificity

Published:2015-03-06 Issue:3 Volume:466 Page:587-599
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

Charoensuksai Purin¹,Kuhn Peter¹²,Wang Lu¹,Sherer Nathan¹,Xu Wei¹

Affiliation:

1. McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, U.S.A.

2. Biological Sciences Department, Edgewood College, Madison, WI 53711, U.S.A.

Abstract

O-GlcNAcylation (O-linked-β-N-acetylglucosaminidation) sites of CARM1 (co-activator-associated arginine methyltransferase 1) have been mapped to four possible sites. O-GlcNAc (O-linked-β-N-acetylglucosamine)-depleted CARM1 generated by three different methods displays different substrate specificity from that of wild-type CARM1, suggesting that O-GlcNAcylation of CARM1 is an important determinant for CARM1 substrate specificity.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/466/3/587/736140/bj4660587.pdf

Reference69 articles.

1. Regulation of transcription by a protein methyltransferase;Chen;Science,1999

2. Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17;Miao;Mol. Endocrinol.,2006

3. Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53;An;Cell,2004

4. Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities;Koh;J. Biol. Chem.,2001

5. CARM1 promotes adipocyte differentiation by coactivating PPARgamma;Yadav;EMBO Rep.,2008

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. O-GlcNAcylation: the sweet side of epigenetics;Epigenetics & Chromatin;2023-12-14

2. Protein arginine methylation in viral infection and antiviral immunity;International Journal of Biological Sciences;2023

3. Coactivator-associated arginine methyltransferase 1: A versatile player in cell differentiation and development;Genes & Diseases;2022-06

4. O-GlcNAcylation links oncogenic signals and cancer epigenetics;Discover Oncology;2021-11-24

5. CARM1/PRMT4: Making Its Mark beyond Its Function as a Transcriptional Coactivator;Trends in Cell Biology;2021-05