Human atrial natriuretic polypeptide during escape from mineralocorticoid excess in man

Author:

Miyamori Isamu1,Ikeda Masatoshi1,Matsubara Takao1,Okamoto Shinya1,Koshida Hideo1,Morise Toshio1,Takeda Ryoyu1

Affiliation:

1. Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan

Abstract

1. Plasma concentrations of human α-atrial natriuretic polypeptide (h-αANP) during escape from the effects of mineralocorticoid excess were determined in six healthy volunteers. 2. Escape, as indicated by an abrupt increase in sodium excretion on the third to sixth day of 9α-fludrocortisone acetate administration (0.6 mg/day), was observed in all subjects. 3. The mean plasma h-αANP level was 30.9 ± sem 8.8 pmol/l on the control day; it increased exponentially in response to 9α-fludrocortisone acetate administration, reached a significant level (114.0 ± 22.4 pmol/l, P < 0.05) on the day before escape and remained elevated during escape. 4. The 24 h creatinine clearance and blood pressure did not change significantly before the escape. Plasma h-αANP increased markedly when the cumulative sodium balance exceeded 220 mmol. 5. These results suggest that h-αANP may play a contributory role in natriuresis and diuresis after mineralocorticoid excess.

Publisher

Portland Press Ltd.

Subject

General Medicine

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