Forced expression of the cyclin B1–CDC2 complex induces proliferation in adult rat cardiomyocytes-Reference-Cited by-同舟云学术

Forced expression of the cyclin B1–CDC2 complex induces proliferation in adult rat cardiomyocytes

Published:2004-08-24 Issue:2 Volume:382 Page:411-416
ISSN:0264-6021
Container-title:Biochemical Journal
language:en
Short-container-title:

Author:

BICKNELL Katrina A.¹,COXON Carmen H.¹,BROOKS Gavin¹

Affiliation:

1. Cardiovascular Research Group, School of Pharmacy, The University of Reading, P.O. Box 228, Whiteknights, Reading, Berkshire RG6 6AJ, U.K.

Abstract

Repair of the mature mammalian myocardium following injury is impaired by the inability of the majority of cardiomyocytes to undergo cell division. We show that overexpression of the cyclin B1–CDC2 (cell division cycle 2 kinase) complex re-initiates cell division in adult cardiomyocytes. Thus strategies targeting the cyclin B1–CDC2 complex might re-initiate cell division in mature cardiomyocytes in vivo and facilitate myocardial regeneration following injury.

Publisher

Portland Press Ltd.

Subject

Cell Biology,Molecular Biology,Biochemistry

Link

https://portlandpress.com/biochemj/article-pdf/382/2/411/717917/bj3820411.pdf

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