PECULIARITIES OF IMMUNE REGULATION AND GENETIC POLYMORPHISM OF ADULT POPULATION LIVING IN THE CONDITIONS OF VANADIUM EXTERNAL EXPOSURE-Reference-Cited by-同舟云学术

PECULIARITIES OF IMMUNE REGULATION AND GENETIC POLYMORPHISM OF ADULT POPULATION LIVING IN THE CONDITIONS OF VANADIUM EXTERNAL EXPOSURE

Published:2018-11 Issue: Volume: Page:27-30
ISSN:2619-0788
Container-title:ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT
language:ru
Short-container-title:PH&LE

Author:

Dolgikh О.V.,Starkova К.G.,Каzakova О.А.,Krivtsov А.V.,Otavina Е.А.,Mazunina А.А.

Abstract

We conducted the survey of the adult population (n = 37) at age of 33.82 ± 0.82 years, living in ecologically unfavorable conditions (influence zone of industrial emissions) of Chusovoy (Perm Territory). The comparison group included 25 people from the area with acceptable sanitary and hygienic indicators of atmospheric air quality. The average age of the comparison groups surveyed was 35.25 ± 1.24 years. The study of features of the immune status of the examined individuals exposed to the external effects of vanadium fine dust have been showed a decrease in phagocytosis, expression of the level of interleukin-10 and production of serum immunoglobulin A class (IgA). Both the odds ratio analysis and mathematical modeling showed a significant increase in the content of class G immunoglobulin (IgG) and class M immunoglobulin (IgM) (R2 = 0.67–0.70, p < 0.05) with an increase of vanadium concentration in the blood. At the same time, the study of the metal content in the blood of the observed group as compared with the permissible level showed higher concentrations. We revealed the features of gene polymorphism associated with an increase in the prevalence of the minor homozygous genotype for the SULT1A1 and CYP1A1*3 genes — the immune regulation (MTHFR), detoxification and endothelial regulation (VEGFA) genes. The results of the analysis of twenty-nine polymorphic genes revealed the key genes of the male and female subgroups of the main group, which prevalence of polymorphisms was significantly different from that of the comparison group (p < 0.05). At the same time, the genotypes of working men of the main group were characterized by a significant predominance of the variant allele compared to the control group (HTR2A, MTHFR, CYP1A1, FAS, CPOX, TNF). The genotypes of working women were characterized by the dominance of such polymorphic genes as MTHFR, MMP, ANKK1, ZMPSTE, TNF.

Publisher

Federal Center for Hygiene and Epidemiology

Reference46 articles.

1. Dolgikh O.V., Krivtsov A.V., Starkova K.G., Bubnova O.A., Dianova D.G., Vdovina N.A., Ukhabov V.M. Immunogeneticheskie izmeneniya u rabotayushchikh v usloviyakh sochetannogo vozdeistviya proizvodstvennogo shuma i pyli [Immunogenetic changes in workers under the combined effects of occupational noise and dust]. Meditsina truda i promyshlennaya ekologiya, 2015, no. 12, pp. 21–25. (In Russ.)

2. Dolgikh O.V., Krivtsov A.V., Kharakhorina R.A. Immunnye i DNK-markery vozdeistviya tekhnogennoi nagruzki [Immune and DNA markers of anthropogenic stress]. Vestnik Ural'skoi meditsinskoi akademicheskoi nauki, 2012, no.4, pp. 240–241. (In Russ.)

3. Dolgikh O.V., Starkova K.G., Krivtsov A.V., Bubnova O.A. Variabel'nost' immunoregulyatornykh i geneticheskikh markerov v usloviyakh kombinirovannogo vozdeistviya faktorov proizvodstvennoi sredy [Variability of immunoregulatory and genetic markers in conditions of the combined influence of the production environment factors]. Gigiena i sanitariya, 2016, Vol. 95, no. 1, pp. 45–48. (In Russ.)

4. Izmerenie massovykh kontsentratsii khimicheskikh elementov v biosredakh (krov', mocha) metodom mass-spektrometrii s induktivno svyazannoi plazmoi: MUK 4.1.3230–14 (utv. Postanovleniem Glavnogo gosudarstvennogo sanitarnogo vracha Rossiiskoi Federatsii A.Yu. Popovoi ot 19.12.2014) [Methodological guidelines 4.1.3230–14 Measurement of mass concentrations of chemical elements in biological media (blood, urine) by mass spectrometry with inductively coupled plasma (approved by the Resolution of the Chief State Sanitary Doctor of the Russian Federation A.Yu. Popova dated 12.19.2014). Moskva, 2014. (In Russ.)

5. Kazantseva L.K., Tagaeva T.O. Sostoyanie okruzhayushchei sredy i zdorov'ya naseleniya v rossiiskikh regionakh [The state of the environment and public health in the Russian regions]. Sovremennye issledovaniya sotsial'nykh problem, 2011, Vol. 8, no.4, pp. 46–59. (In Russ.)