Author:
Riaz Sara,Jahangir Sana,Hamza Uzma,Raza Irum,Jabran Aamna
Abstract
One of the most feared side effects of contemporary cataract surgery is still endophthalmitis. Prophylactic measures include the use of antibiotics: topical, subconjunctival, and intracameral, to avoid endophthalmitis. Moxifloxacin 0.5% has been used most frequently in preventive late-stage regimens. Objective: To ascertain how well moxifloxacin prevented endophthalmitis in patients having cataract surgery. Methods: This was a descriptive case study and was conducted at Eye Departments of Allama Iqbal Medical College, Jinnah Hospital, Lahore and Ameer-ud-Din Medical College, Lahore General Hospital, Lahore. The study was commenced after approval of the synopsis and completed in 6 months. Results: In this study, 23.75%(n=19) were between 40-50 years, 61.25%(n=49) between 51-60 years and 15%(n=12) had >60 years of age, and their average was calculated as 53.99+6.22 years. 58.76%(n=47) were males and 41.25%(n=33) were females in the study. Mean endothelial cell count before cataract surgery was calculated as 2776 +177 while post-operative the average endothelial count was calculated as 2424 +72.8. while the frequency of effect of moxifloxacin, in the prevention of endophthalmitis in patients undergoing cataract surgery was recorded as 22.5%(n=18) while 77.5%(n=62) had no effect of moxifloxacin while preventing endophthalmitis in patients undergoing cataract surgery. Conclusions: We conclude that the effect of moxifloxacin, in preventing endophthalmitis in patients undergoing phacoemulsification surgery is not significantly higher and may be used in our setup for prevention of endophthalmitis, being a risk factor for blindness. Moxifloxacin does not affect the corneal endothelial cells significantly.
Publisher
CrossLinks International Publishers
Reference20 articles.
1. Ali MH, Javaid M, Jamal S, Butt NH. Femtosecond laser assisted cataract surgery, beginning of a new era in cataract surgery. Oman Journal of Ophthalmology. 2015 Sep; 8(3): 141. doi: 10.4103/0974-620X.169892.
2. Jabbarvand M. Endophthalmitis Occurring after Cataract Surgery: Outcomes of More Than 480 000 Cataract Surgeries, Epidemiologic Features, and Risk Factors. Ophthalmology. 2016 May; 123(5): 1168-. doi: 10.1016/j.ophtha.2015.08.023.
3. Ali MH, Ullah S, Javaid U, Javaid M, Jamal S, Butt NH. Comparison of characteristics of femtosecond laser-assisted anterior capsulotomy versus manual continuous curvilinear capsulorrhexis: A meta-analysis of 5-year results. JPMA. The Journal of the Pakistan Medical Association. 2017 Oct; 67(10): 1574-9.
4. Rathi VM, Sharma S, Das T, Khanna RC. Endophthalmitis Prophylaxis Study, Report 2: Intracameral antibiotic prophylaxis with or without postoperative topical antibiotic in cataract surgery. Indian Journal of Ophthalmology. 2020 Nov; 68(11): 2451. doi: 10.4103/ijo.IJO_1738_19.
5. Grzybowski A, Turczynowska M, Schwartz SG, Relhan N, Flynn HW. The role of systemic antimicrobials in the treatment of endophthalmitis: a review and an international perspective. Ophthalmology and Therapy. 2020 Sep; 9: 485-98. doi: 10.1007/s40123-020-00270-w.