Prevalence of Impaired Glucose Tolerance/Prediabetes in Local Adult Obese Population Presenting to A Tertiary Care Hospital

Abstract

Obesity is affecting all countries across the globe and becoming an epidemic. It is a major factor contributing to metabolic disorders, diabetes and cardiovascular diseases (CVD). In Pakistan, CVD has highest mortalities which is closely related to obesity and diabetes. Objective: To determine the frequency of impaired glucose tolerance (IGT) in local adult obese population. A cross sectional, descriptive study was designed department of Medicine, Hayatabad Medical Complex, Peshawar. Methods: A total of 136 patients with BMI of more than 25kg/m2 in Medical OPD with age between 18-60 years were included. Weight and height were measured for obesity and BMI calculation. All patients were subjected to 75gm oral glucose tolerance test after 08 hours overnight fast. Venous blood was withdrawn before and after the oral glucose solution and IGT were considered positive if the blood glucose level is between 140- 199mg/dl at 2-hour post oral glucose solution. Results: 136 patients were analyzed in which 42(31%) patients were having age between 18-40 years, 94(69%) patients were having age between 41-60 years. Mean age was 53 years with SD ± 10.44. Forty-nine (36%) patients were male and 87(64%) patients were female. Moreover 24(20%) patients had IGT while 112(80%) patients had normal glucose tolerance. Conclusion: Impaired glucose tolerance was found in 20% of adult obese population. The exponential rise from obesity 1 patients having 8% and obesity 3 patients having 57% IGT shows significantly increased risk.