Correlation of Menopausal Symptoms with Serum Estradiol in Pre and Postmenopausal Women of Nawabshah (SBA)

Abstract

The term menopause accurately incomes termination of menstrual cycle. A diversity of physiological changes proceeds in the body, certain of these are the consequence of cessation of ovarian function and decreased production of estrogen. Objective: To determine the serum estrogen levels and to study menopause related symptoms in pre and postmenopausal women due to declined estrogen levels. Methods: This was a cross sectional study. Participants were recruited from the Gynecology and Obstetrics and Medicine OPD/Ward PMCH and from the general public.  After explaining the study's goal to all participants, they gave their written and verbal agreement. Blood samples were collected for biochemical testing and stored at -20℃ in the laboratory. ANOVA test was applied for comparison of estrogen among the study participants. This study involved 400 individuals who were separated into two groups, Premenopause and Postmenopause. Results: The mean ±SD of age of Premenopausal participants was 44.44±2.61 years and the mean ±SD of Postmenopausal females remained 54.78±2.80 years. The mean value of serum estradiol of pre and postmenopausal participants was noted as 13.03±11.42 pg/ml 8.21±4.7 pg/ml. The predominant symptoms among the premenopausal women experienced were depressive mood and irritability (61%) while the symptoms experienced by postmenopausal women were dryness of vagina (59%) and heart discomfort (54%). Conclusions: The decrease in estrogen may lead to symptoms like vaginal dryness, mood changes, night sweats and hot flashes. The symptoms experienced are similar as elsewhere in the world, although occurring with varying frequencies.