Author:
Ghazanfar Masuma,Sarwar Hamid,Cheema Muhammad Hassan,Cheema Muhammad Hussnain,Fatima Noor,Sheikh Ali Husnain
Abstract
Idiopathic Thrombocytopenia Purpura (ITP), an autoimmune bleeding disorder, affects both children and adults, categorized into acute, persistent or chronic types based on symptom duration. Clinical presentations vary widely, ranging from minor bleeds to severe systemic hemorrhages involving CNS, GIT and genitourinary tract. Objective: To assess clinical manifestations in ITP patients at a Lahore tertiary care Hematology department. Methods: This retrospective cross-sectional study included data from 660 diagnosed ITP patients from January 2020 to December 2022 using consecutive sampling technique at Allama Iqbal Medical College. Data were recorded after taking consent from patients. Results: Mean age was 31.8 ± 12.8 SD, with 10.3% children and 89.7% adults. Patients were categorized based on platelet counts into mild, moderate, and severe groups. Most children (47%) and adults (59.9%) had moderate thrombocytopenia. Common features included bruising in children (67.6%), gum bleeding (77%) in adults of both sexes and menorrhagia (67.9%) in females. Conclusions: ITP affects all ages but predominantly females. Clinical presentation varies, with most cases showing superficial bleeding like bruising, epistaxis, gum bleeding, or menorrhagia in females.
Publisher
CrossLinks International Publishers
Reference20 articles.
1. Champatiray J, Behera DK, Krishnamoorthy A, Bhat S. Evaluation of prevalence, clinical spectrum and outcome of acute ITP in children in a tertiary care centre in Odisha, India. International Journal of Contemporary Pediatrics. 2017 Jul; 4(4): 1470-5. doi: 10.18203/2349-3291.ijcp20172688.
2. Ejaz A and Radia D. Diagnosis and management of primary immune thrombocytopenia in adults. British Journal of Hospital Medicine. 2019 Apr; 80(4): C54-7. doi: 10.12968/hmed.2019.80.4.C54.
3. Cooper N. State of the art-how I manage immune thrombocytopenia. British Journal of Haematology. 2017 Apr; 177(1): 39-54. doi: 10.1111/bjh.14515.
4. Rashid N, Imtiaz U, Iqbal I, Malik A, Khalid A, Mobeen S. Spectrum of skin manifestations in patients presenting with idiopathic thrombocytopenic purpura in a tertiary care hospital. Journal of Pakistan Association of Dermatologists. 2020 Sep; 30(2): 286-8.
5. Pamuk G, Pamuk Ö, Başlar Z, Öngören Ş, Soysal T, Ferhanoğlu B et al. Overview of 321 patients with idiopathic thrombocytopenic purpura: retrospective analysis of the clinical features and response to therapy. Annals of Hematology. 2002 Aug; 81: 436-40. doi: 10.1007/s00277-002-0488-x.