Comparison of Clinical Response to D-Mannose with Behavioral Modifications Versus Behavioral Modifications Alone in Asymptomatic Pyuria During Pregnancy

Abstract

The physiological and structural changes during pregnancy cause ureteral dilatation and urine stasis, which can lead to asymptomatic and symptomatic infections. Objective: To compare the clinical response between d-mannose with behavioral modifications versus behavioral modifications alone in asymptomatic pyuria during pregnancy. Methods: A quasi experimental study was conducted from April to September 2021, in the Department of Gynecology and Obstetrics Maternal and Child Health Center unit-1, PIMS, Islamabad. A total of 130 women with diagnoses of asymptomatic pyuria matching the inclusion criteria were recruited during  study period and assigned to two groups by consecutive non-probability sampling method. Patients with urinary tract abnormalities, GDM, and antibiotic-treated symptomatic UTIs were excluded. Group A was instructed to take 1 g of D-mannose twice daily and follow the advises about behavioral changes.The group B was instrcucted to follow behavioral change only.  pus cells in urine R.E.reports were used to  evaluate response of treatments. Results: According to the study, the mean age of patients in group A was 27.69 ± 4.04 years, whereas group B had a mean age of 28.85 ± 4.12 years. The majority of patients (61.54%) were aged 15-30. Patients in group A had a mean gestational age of 23.72 ± 3.19 weeks, whereas group B had 24.26 ± 3.23 weeks. Patients had a mean BMI of 29.65 ± 3.55 kg/m2. In group A; 23 (35.18%) and in group B 11 (16.92%) cases of asymptomatic pyuria achieved reolution.Conclusions: This study found that D-mannose with behavioral adjustments resolves asymptomatic  pyuria during pregnancy better than behavioral modifications alone.