Evaluation of Cardiac Profile in CCl4 Induced Toxicity in Albino Rats

Abstract

The use of consumer and fumigant products like CCl4 has been phased down, leaving only industrial usage. It is extremely harmful to one's health. It's also one of the most toxic substances in vital organs like the lungs, kidneys, liver, heart, and brain. Objective: To evaluate the cardiac profile in CCl4-induced toxicity in albino rats. Methods: The research was conducted at animal home of Department of Zoology, University of Okara. The targeted victims were albino rats. There were two types of groups created: control group and experimental group. The rats were fed 30 percent diluted carbon tetrachloride with normal saline as a control group to see if it had an adverse effect on their cardiac profile. A 12-day trek was used to accomplish this. After 12 days, samples were taken or dissected to assess serum Creatine Kinase (CPK), (CK-MB), and (LDH). The samples were analyzed by a machine called Micro-Lab 300 after they were taken by puncturing the Rats' hearts. Results: Abnormal increased level for Creatine Kinase (CPK) (199.20 ± 1.93) was observed after the administration of CCl4 compared to normal control (71.60 ± 4.04). When CCl4 was injected, the level of CK-MB was abnormally high (34.00 ± 1.21) compared to the normal control (16.00± .84). The level of LDH increased abnormally (291.60 ± 5.01) when CCl4 was given, compared to the normal control (250.20± 2.16). Conclusions: The levels of Creatine Kinase (CPK), CK-MB, and LDH were found to be greater than normal, showing that CCl4 is hazardous to rats cardiac profile.