Protective Potential of Ashwagandha, Against Pyrifluquinazon Induced Hepato-And Nephrotoxicity in Albino Mice

Abstract

Globally, due to rise in dependence on the agricultural sector for food supply, the use of insecticides i.e., “Chemicals used to kill insects”, has been increasing day by day. One of these is Pyrifluquinazon. The emerging concern is that after field spray, this insecticide has the tendency to be incorporated into surface water and become a part of the food chain and so becomes toxic for both aquatic and terrestrial organisms. Objective: To investigate the protective potential of Ashwagandha against damaging effect of Pyrifluquinazon (PQZ) on liver and kidney of mature and healthy male albino mice. Methods: Albino mice were divided into four groups, each group contained five mice. First group was control, supplied with water while, three were treated groups (Dose, Dose + Antidote and Antidote group respectively) to check protective potential of Ashwagandha against PQZ induced hepato and nephrotoxicity in mice. The dose group was supplied with PQZ while Dose + Antidote group with PQZ and Ashwagandha as an antidote while the Antidote group was supplied with Ashwagandha. This was accomplished for 20 days trial. Blood sampling and dissection was done at 20th day. Blood sample were taken using intra cardiac sampling method for biochemistry while liver and kidney were separated from each group for histopathological studies. Results: The liver function test and kidney function were normal and indicated restoration of their normal function. Histopathological findings also revealed regeneration in damaged areas of liver and kidney tissues. Conclusions: The Findings of this study clearly revealed the protective potential of Ashwagandha against PQZ induced hepato and nephrotoxicity.