Estimation of Lipid Profile in CCl4 Induced Toxicity in Albino Rats

Abstract

The combination of chlorine and chloroform in the presence of light produces carbon tetrachloride (CCl4), a colorless, volatile, non-inflammable liquid. It is a clear liquid with a sweet odor that can be perceived at low levels and does not occur naturally. It poses a significant hazard to one's health and is also one of the leading sources of toxicity in critical organs such as the lungs, kidneys, liver, and brain. Objectives: To determine the lipid profile with CCl4-induced in albino rats. Methods: The research was conducted at the University of Okara, Department of Zoology. The experiment was conducted at the animal home of the Department of Zoology, University of Okara. Albino Rats were the intended targets. There were two groups created: a control group and an experimental group. To test the harmful effect on the lipid profile, the rats were fed 30 per cent diluted carbon tetrachloride, with normal saline as a control group. This was accomplished through a 12-day trial. Sampling or dissection was done after 12 days to determine serum Total Cholesterol, Triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL). Rats were dissected, and their hearts were punctured to obtain a blood sample and organs. After sampling was taken by puncturing the Rats' hearts, the samples were examined by a machine called Micro-Lab 300. Results: Total Cholesterol, Triglycerides, HDL, and LDL levels were higher than usual. Conclusions: The study indicated that CCl4 has a toxic effect on the lipid profile of rats.