Biological Characterization of Colorectal Cancer in Patients Undergoing Surgery and Its Correlation with Gender and Age

Abstract

Among cancer patients’ colorectal carcinoma abbreviated as CRC is the one of the chief cause of death Objective: To study the biological characteristics and types of colorectal cancer, and its correlation with various age groups and gender. Methods: It was descriptive study carried out in different surgical units of LUMHS Jamshoro, Sindh for period of 2 years including 115 patients. Biopsy was performed to diagnose colorectal carcinoma after getting consent from patients and the immune histochemical analysis was performed. Results: The age range of patients diagnosed with colorectal cancer were  above 60 years males. Majority of patients showed per rectal bleeding with positive family history. Patients were also observed to be associated with different types of colorectal carcinomas including rectal, mucinous, well differentiated, moderately differentiated and poorly differentiated. The analysis of TNM classification showed majority at in stage II, also some were in stage 1V (8.09%). The biological markers showed P53 and BCL2 the most common and cytokeratin and P53 were found significantly positive in age group of 31-45yeras and 46-60 years Additionally, HER2, P53 VEGF showed significantly (p=0.05) higher rates in males. Conclusion: Mucinous carcinoma was most common colorectal cancer, and biological markers P53 and BCL2 were frequently common.