Apolipoprotein B and Lipid Profile among Patients Diagnosed with Acute Myocardial Infarction

Abstract

Highest mortality rates are associated with acute myocardial infraction. It is recognized as leading cause of deaths globally. It is sequelae to the atherosclerosis cardiovascular disease (ASCVD). There is a close relationship between the Apo lipoprotein B abundance and atherosclerosis. Objectives: To estimate the ApoB blood levels and its usefulness and to analyze the total cholesterol TC, non-HDL cholesterol, triglycerides, high density lipoprotein cholesterol (HDL-C), LDL/HDL and low density lipoprotein cholesterol (LDL-C) ratios in AMI patients. Methods: It was a comparative cross-sectional study with statistical approach, conducted at Akbar Niazi Teaching Hospital, Islamabad and Khyber Teaching Hospital, Peshawar. The study was conducted on the 53 males and 28 female attended the cardiovascular center of the hospital. The duration of the study was from December 2021 to May 2022. The convenient sampling technique was used for the sampling of the enrolled patients. The healthy patients were included in the control group. The tubidimetric method was laboratory analysis and for lipid profiling the Apolipoprotein B and enzymatic method was used. The SPSS version 21.0 was used for the statistical analysis. Results: The ratio of males to females was 1.8:1. The Myocardial infarction range of the patients was selected from more than 31 years to 84 years. The 55  10 was the average age of the patients included in the study. However, 61 years of age was the median and the interquartile limit was 46 to 61 years for male patients, and for female patients was 49 to 68 years. Of 93 patients (6.5 %) the sufferers were of age lower than 40 years, 46 patients were smokers in the experimental group and in the control group, only 15 people were smokers. The 99 ± 17.8 was the mean level and SD of the experimental group. The moderate correlation was observed in the ApoB, non-HDL cholesterol and HDL-cholesterol. Conclusions: The moderate correlation between Apo B and non HDL-C and HDL-C were observed in the AMI patients. It was a complementary marker in the conventional lipid profiling