Bacteriological Profile and Drug Resistance Pattern of Isolates of ICU Patients In Hospital Of Peshawar

Abstract

Multidrug-resistant infectious diseases are one of the top causes of death and morbidity among hospitalized patients worldwide. Objective: This study’s aim was to assess the frequency of common bacterial pathogens, as well as their antibiotic sensitivity & resistance, in various Intensive care unit tertiary care hospitals. Methods: The current investigation was conducted from February to May 2021 in multiple ICU at a primary care hospital in Peshawar. Patients who were admitted to any of the hospital's four intensive care units (ICUs) and patients medically speculated of having an infection within 48 hours of arrival were included. Patients' laboratory samples were selected based on clinical suspicion. Antibiotic sensitivity testing was performed on the samples. Result: E. coli 33(26) was the most commonly isolated bacteria across all samples. “In NICU, CONS 17(67.78), in 7(28.28), in MICU, PICU E. coli, E. coli, Pseudomonas spp and Acinetobacter spp.11(22.39), and in E. coli, SICU 17(46.82) were predominantly isolated” “Amikacin 29(88.6), Cefuroxime 21(65), Klebsiella sp. to Cefoperazone+Salbactum 15(79), Pseudomonas to Tazobactum+Piperacillin 12(66), and Acinetobacter sp. to Sulbactum+Cefoperazone 12(66) are commonly used antibiotics against E. coli 12(56)”. Citrobacter spp. (67.8) was observed more followed by Proteus spp. (34.4) and Enterococcus (34.4). Conclusion: In the ICUs, infectious diseases and antimicrobial resistance are key barriers to patient outcome multidrug-resistant as well as expenditure. All intensive care units throughout the world face the issue of lowering the same.