Prevalence Of Hypothyroidism in Esrd Patients with Maintenance Hemodialysis

Abstract

The kidney affects “the thyroid gland causing various derangements in its function whenever the kidney is impaired, even with a minor imperfection in its job, and this makes dialysis patients more prone to thyroid disorders with subsequent increase in mortality and morbidity. Objective: To determine the frequency of hypothyroidism in ESRD patients who are on maintenance hemodialysis. Methods: A descriptive cross-sectional study was conducted at Department of Nephrology, Liaquat University of Medical and Health Sciences Jamshoro”, upon a sample of 140 patients having age between 18 to 70 years presented with end stage renal disease with 3 months or more of maintenance hemodialysis were consecutively enrolled. Investigations was advised for TSH levels, T3, T4. The presence of hypothyroidism along with baseline and clinical characteristics were noted. Results: Of 140 patients, the mean age of the sample was 62.31± 9.78 years. Majority of the sample were males as compared to females, i.e., 93 (66.4%) and 47 (33.6%). History of thyroid disorder was observed in 83 (59.3%) patients. Comorbidity showed that type 2 diabetes mellitus was observed in 65 (46.4%) and hypertension in 77 (55%) patients. The mean TSH, T3 and T4 level was found to be 4.67± 0.20, 0.97± 0.37, and 5.33± 0.69 respectively. Frequency of hypothyroidism was found to be 53 (37.9%) patients. Conclusion: A considerably higher number of patients were presented with hypothyroidism in “ESRD patients who are on maintenance hemodialysis.