Characterization of Taste Receptor Class 2 genes in Mouse [Mus musculus]

Abstract

Because the amino acid sequence of mouse specie is closely related to human genes therefore, we use it as a role model for doing research related to human genome in improving the standards of life. The T2R receptors belong to the C family of GPCRs, which includes the calcium-sensing receptor (CaSR). All are G protein-coupled receptors but here we are only highlighting the different roles of distantly related receptors of the main taste bud system. Objective: To characterize and analyse the Taste Receptor Class 2 genes in mouse [Mus musculus]. Methods: In order to get insights into this gene family in mouse, we performed an extensive survey of taste receptor derived datasets. We identified 500 genes distributed among mouse encoding putative taste receptor proteins. Results: We characterised 61 vomeronasal type 2 receptor genes in Mus musculus. T2R gene family was found to be highly conserved in this study by using Weblogo tool. Also, a broad view of GABA inhibitory taste buds was observed. It evolved at the level of eukaryotes. The T2R is involved mainly in taste sensation. We also see protein-protein interaction using string database. Conclusions: The basic repertoire of T2R genes seems to be larger for most of the species including mouse and gene duplication still plays a role in lineage-specific increases in diversity. T2R gene family is very ancient, has high duplicability suggesting its essentiality as well as high protein interaction for TsR2 gene.