Antibacterial Activities of Various Antibiotics Against Klebsiella pneumoniae in Clinical Isolates

Abstract

Antibiotic resistance is not a latest phenomenon, since the introduction of antibiotics, bacteria are noted to posses some resistance. Antibiotic resistance refers to bacteria's capacity to withstand the effects of antibiotics. Objective: To compare the antibacterial effects of different drugs on Klebsiella pneumoniae clinical isolates. Methods: A cross-sectional investigation was conducted in a hospital in Lahore, Pakistan, collecting 1,400 samples over the course of a year. Antibiotic susceptibility testing was performed using the Kirby-Bauer disc diffusion method. Results: The results showed that Imipenem, Gentamycin, Amikacin, Augmentin, Linezolid, Levofloxacin, Ceftazidime, Norfloxacine, and Cefazolin were the most effective antibacterial agents against K. pneumoniae. On the other hand, K. pneumoniae was highly resistant to Meropenem, Cephalothin, Rifampicin, Cefoxitin, and Ampicillin.  Conclusion: The study highlights the growing concern of antibiotic resistance in K. pneumoniae and the importance of preventative measures such as responsible use of antibiotics, development of new treatments, and implementation of infection control strategies in healthcare settings to effectively manage and prevent the spread of resistance