Biochemical Effects of Oral Contraceptive Pills on Serum Bilirubin, Creatinine and Antioxidants System Among Females

Abstract

Both estrogens and progestogens antifertility agents are used by huge number of females. Excessive use of antifertility agents caused toxic effects on body systems. Liver play its key role in the metabolic process of these toxic antifertility agents. Objective: To examine the biochemical effects of oral contraceptive pills on serum bilirubin, creatinine and antioxidants system among females. Methods: Participants of the study were categorized in to two groups i.e. control group (CG) (female using no contraceptive pills) and experimental group (EG) (females using contraceptive pills). Five (05) ml of blood was collected from each subject by vein cut and an expendable syringe. All blood samples were marked with separate identification code or mark. Ferric reducing assay protocol (FRAP) was applied for measuring oxidative stress and liver functions test (LFTs) was performed for measuring serum bilirubin and creatinine. Results: The collected data were tabulated and were analyzed by using mean, standard deviation, frequency and percentage etc. through the application of statistical package for social sciences (SPSS, version-26.0). Conclusions: Based on analysis the researcher draws the conclusion that oral contraceptive pills (OCP) have significant effect on serum bilirubin (p-value was 0.004), serum creatinine (p-value 0.023) and oxidative stress (p-value 0.002).