Association of Polymorphic Gene Variants of Xenobiotic Biotransformation Enzymes with Lung Tissue Destruction in Tuberculosis Patients-Reference-Cited by-同舟云学术

Association of Polymorphic Gene Variants of Xenobiotic Biotransformation Enzymes with Lung Tissue Destruction in Tuberculosis Patients

Published:2022-09-09 Issue:8 Volume:100 Page:25-30
ISSN:2542-1506
Container-title:Tuberculosis and Lung Diseases
language:
Short-container-title:Tuberk. bolezni lëgk.

Author:

Alymenko M. A.¹,Valiev R. Sh.¹,Valiev N. R.¹,Polonikov A. V.²,Tragira I. N.³,Sheenkov N. V.⁴

Affiliation:

1. Kazan State Medical Academy, Branch of Russian Medical Academy of Continuing Professional Education

2. Research Institute of Genetic and Molecular Epidemiology, Kursk State Medical University

3. National Medical Research Center of Phthisiopulmonology and Infectious Diseases

4. The Gamaleya National Center of Epidemiology and Microbiology

Abstract

The objective: to investigate the association of polymorphic gene variants of xenobiotic biotransformation enzymes (NAT2, CYP2E1, ABCB1, GSTM1, GSTT1) and cytokines (IL1B, IL-4, IL-10, TNF) with lung tissue destruction in pulmonary tuberculosis patients.Subjects and Methods. An ethnically homogeneous population sample of unrelated individuals of Slavic nationalities (mainly Russians) living in Kursk Oblast suffering from new pulmonary tuberculosis was examined.Results. New pulmonary tuberculosis with no destructive changes in the lungs was associated with the EE genotype of the GSTM1 gene (p < 0.0001) in 89.5%, while the DD genotype of the GSTM1 gene (p < 0.0001) was associated with the presence of destructive changes in the lungs in 56.1% of cases; the dominant GG genotype of the TNF-α gene was associated with destructive changes in the lungs in 93.3% (p = 0.027), and the recessive GA genotype of the TNF-α gene was associated with no destructive changes in the lungs in 71.9% (p = 0.027).

Publisher

LLC "Medical Knowledge and Technologies"

Subject

General Medicine

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